Fat cells survive ‘thin’ cells

Surviving cells with a high fat content ‘thin’ cells, according to new research. This confirms the ‘obesity paradox’: the phenomenon of overweight people a better prognosis and longer life seem to have than slim people.

fat cell

Overweight people better prognosis

This study by Michigan State University could have implications for humans, because the results confirm a phenomenon called obesity paradox; this means that patients with overweight and obese patients a slight better prognosis seem to have then leaner patients.

“The obesity paradox brings scientists puzzled. But yeast -an excellent model for studies of human veroudering- extend an increased cellular content of triacylglycerol lifetime, “said study author Min-Hao Kuo, biochemist and molecular biologist.

Kuo and his team are the first to show a positive correlation between triacylglycerol, content and longevity. This connection supports the obesity paradox theory.

fat cell

Triacylglycerol (TAG), is a fat in which all eukaryotic cells (complex cells with nuclei, all human beings, animals, plants, and fungi, eukaryotic cells). This type of fat stores excess energy, isolate and accumulates in response to many stressors. Astonishingly, however, is how triacylglycerol affects the lifetime.

Kuo: “Our team used genetic approaches to manipulate the cellular capacity of reproduction and degradation of TAG. Through sophisticated analysis, we found that this fat life sustains through a mechanism that is largely independent of other mechanisms that regulate lifespan, as usual in both yeast and humans. ”

The first thing that Kuo did was the removal of TAG-lipase enzymes that break down the lipid to smaller molecules for various purposes. Now Yeast no TAG could use more, hoping the fat within the cells. Kuo and his team then boostten to bring the production of fat, TAG synthesis achieved.

By blocking the degradation of TAG and to force the production, yeast cells are thicker, and they have a longer life. Yeast cells which are unable to synthesize TAG are thin, but die young.

Also interesting is that the fat and long-lived yeast cells do not appear to suffer from significant growth defects. They reproduce well and have a normal resistance to various stressors. Calorie restriction often leads to slow cell growth or less permissive cells compared to environmental stress.